casr antibody
casr antibody
CASR Antigen Profile calcium sensing receptor CASR antibody calcium-sensing receptor Casr antibody calcium-sensing receptor L homeolog casrL antibody calcium sensing receptor Casr antibody
CASR
Frontiers
Introduction
Mapping of human autoantibody binding sites on the calcium
· Clinical trials targeting CD19 on B-cell malignancies are underway with encouraging anti-tumor responses Most infuse T cells genetically modified to express a chimeric antigen receptor CAR with specificity derived from the scFv region of a CD19-specific mouse monoclonal antibody mAb clone FMC63 We describe a novel anti-idiotype monoclonal antibody mAb to detect CD19-specific CAR+ T
Antibody information for antibodies HPA039686 and HPA050335 used in analysis of ENSG00000036828 / CASR FHH, GPRC2A, HHC, HHC1, NSHPT
Chimeric antigen receptor T cell
· Anti-CaSR antibody and anti-CaSR mAb were used as positive controls in phage ELISA against phage displaying either peptide 1–36 or peptide 210–241 respectively An antibody index was calculated for each serum and the upper limit of normal for each phage ELISA was determined Any serum sample with an antibody index above the upper limit of normal was designated as positive for antibody reactivity to the phage-displayed CaSR …
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Autoimmune Hypercalcemia Due to Autoantibodies Against the
Antibody Video 2002
Indeed activating CaSR autoantibodies were detected in a patient with primary hypoparathyroidism receiving nivolumab “Anti-parathyroid antibodies have been described in patients with autoimmune endocrine conditions such as Addison’s disease and Hashimoto’s thyroiditis as well as cases of idiopathic hyoparathyroidism and animal models of autoimmune hypoparathyroidism,
Kokumi Substances Enhancers of Basic Tastes Induce
Hypoparathyroidism occurs in 80% of patients with APS1 and has been suggested to result from an autoimmune reaction against the calcium-sensing receptor CaSR on parathyroid cells However the detection of CaSR antibodies in APS1 remains controversial with some studies disputing the …
Cited by : 130
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casr
Product Overview anti-CASR Antibodies
· CaSR was detected using a specific antibody generated in our lab host = rat The anti-mouse-CaSR antibody recognizes the protein sequences: KSNSEDPFPQPERQKQQ QGPMVGDHQPEIESPDE and MRQNSLEAQKSNDTLNR corresponding to residues 917–933 1034–1050 and 994–1010 of the mouse CaSR, respectively, Negative controls without the primary antibody were processed in parallel in every experiment
CAST Antibody PDF
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CAST Antibody Immunohistochemistry of paraffin-embedded human uterine cancer using CAST antibody 16-749 at dilution of 1:100 40x lens Specifications HOST SPECIES: Rabbit SPECIES REACTIVITY: Human IMMUNOGEN: Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human CAST NP_001177371,1 TESTED APPLICATIONS: IHC WB APPLICATIONS: WB: ,1:500 – 1:2000 IHC
Chimeric Antigen Receptor CAR-Specific Monoclonal
History, The first chimeric receptors containing portions of an antibody and the T cell receptor was described in 1987 by Yoshikazu Kuwana et al, at the Institute for Comprehensive Medical Science in Aichi, Japan and independently in 1989 by Gideon Gross and Zelig Eshhar at the Weizmann Institute in Israel, Originally termed “T-bodies,” these early approaches combined an antibody’s ability to
Analysis of the antibody binding sites revealed 2 main epitopes at amino acids 41-69 and 114-126 Preincubation with purified CaSR antibodies against epitope 114-126 resulted in a significant decrease in inositol-1-phophate accumulation upon calcium-stimulation of mammalian cells expressing the CaSR suggesting that the antibodies had receptor-blocking activity Conclusions: AHH is to be
Immune checkpoint-induced hypoparathyroidism: A case from
The calcium-sensing receptor is a target of autoantibodies
Previously we have demonstrated the presence of anti-calcium-sensing receptor CaSR antibodies in patients with autoimmune polyglandular syndrome type 1 APS1 a disease that is characterized in part by hypoparathyroidism involving hypocalcemia hyperphosphatemia, and low serum levels of parathyroid hormone, The aim of this study was to define the binding domains on the CaSR of anti-CaSR antibodies …
Cited by : 20
Mapping of Human Autoantibody Binding Sites on the Calcium