dendritic cell based immunotherapy

Dendritic cell-based immunotherapy

 · Dendritic cells have long been a focus of cancer immunotherapy due to their role in inducing protective adaptive immunity, but cancer vaccines have shown limited efficacy in the past, With the advent of immune checkpoint blockade and the ability to identify patient-specific neoantigens, new vaccines, and combinatorial therapies are being evaluated in the clinic, Dendritic cells are also emerging as critical …

Dendritic Cell–Based Immunotherapy: State of the Art and

Dendritic cell-based immunotherapy

 · Dendritic cell-based immunotherapy DC immunotherapy, The role of the immune system in eliminating tumors has been established in several studies, First, Current approaches, Current methods for generating DCs used in the clinical trials include differentiation from monocyte Future approaches,

[Dendritic cell-based cancer immunotherapy]

Frontiers

Dendritic cells based immunotherapy

Dendritic cells DCs are the most potent antigen-presenting cells, and tumor antigen-loaded DCs DC-vaccines can activate tumor-specific cytotoxic T lymphocytes CTLs in lymphatic tissues, DC vaccination is a newly emerging and potent form of cancer immunotherapy and has clinically relevant mechanisms of action with great potential for the systemic treatment of cancers, However, clinical trials have demonstrated …

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Dendritic Cell-Based Immunotherapy: State of the Art and

 · Dendritic cell DC vaccination in cancer patients aims to induce or augment an effective antitumor immune response against tumor antigens and was first explored in a clinical trial in the 1990s More than two decades later numerous clinical trials have been performed or are ongoing with a wide variety of DC subsets culture protocols, and treatment regimens, The safety of DC vaccination and its ability to induce …

Dendritic cell-based glioma immunotherapy review

Dendritic cell DC vaccination in cancer patients aims to induce or augment an effective antitumor immune response against tumor antigens and was first explored in a clinical trial in the 1990s More than two decades later numerous clinical trials have been performed or are ongoing with a wide variety of DC subsets culture protocols, and treatment regimens, The safety of DC vaccination and its ability to induce antitumor …

Immunotherapy using dendritic cell DC-based vaccination is an approved approach for harnessing the potential of a patient’s own immune system to eliminate tumor cells in metastatic hormone-refractory cancer, Overall, although many DC vaccines have been tested in the clinic and proven to be immunogenic, and in some cases associated with clinical

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 · In this context, harnessing dendritic cells DC to treat HIV infection is a promising strategy that has been extensively studied in recent years 5 – 21 , The rationale for using DC is based on their essential role in the immune system, priming a specific immune response 22, 23 ,

Dendritic cell-based immunotherapy for colon cancer using

 · Dendritic cells DCs are professional antigen presenting cells and play an important role in the induction of antigen-specific adaptive immunity However some DC populations are involved in immune regulation and immune tolerance These DC populations are believed to take part in the control of immune exaggeration and immune disorder and maintain immune homeostasis in the body Tolerogenic DCs …

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Current State of Dendritic Cell-Based Immunotherapy

Dendritic cells DCs play a crucial role in the induction of antigen-specific T-cell responses, and therefore their use for the active immunotherapy of malignancies has been studied with considerable interest, More than a decade has passed since the publication of the first clinical data of DC-based vaccines, and through this and subsequent studies, a number of important developmental insights have been gleaned, These include the …

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Dendritic cell-based immunotherapy strategies appear promising as an approach to successfully induce an antitumor immune response and increase survival in patients with glioma Dendritic cell therapy of glioma seems to be safe and without major side effects

Dendritic cell is the most effective antigen presenting cells in human We performed a couple of dendritic cell-based cancer immunotherapy in Tokyo Women’s Medical University Autologous tumor lysates or synthetic peptides are pulsed with dendritic cells to make the dendritic cell vaccine, Tumor-pulsed dendritic cell vaccine TP-DC or peptide pulsed dendritic cell vaccine PP-DC are safe and useful in the patients with advanced cancer, Antigen unpulsed immature dendritic cell …

Dendritic Cell-based Immunotherapy for Rheumatoid

Dendritic cells pulsed with 90K peptides led to the induction of granzyme B and perforin positive CD8+ T cells against HCT116 and SW480 cells but not DLD1 cells In conclusion 90K-specific cytotoxic T lymphocytes generated by stimulating T cells with 90K peptide-pulsed dendritic cells could be useful effector cells for the immunotherapy treatment of colon cancer

Dendritic cell-based immunotherapy

dendritic cell based immunotherapy

 · Dendritic cell DC based cancer immunotherapy aims at the activation of the immune system and in particular tumor-specific cytotoxic T lymphocytes CTLs to eradicate the tumor DCs represent a heterogeneous cell population including conventional DCs cDCs consisting of cDC1s cDC2s plasmacytoid DCs pDCs, and monocyte-derived DCs moDCs,

Dendritic Cells and Their Role in Immunotherapy